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Brian Rose and Ayahuasca Filmmaker Alexander Ward explore the psychedelic DMT (Dimethyltryptamine). They discuss its potential affects, smoke it, and describe their personal journeys and how it has affected their outlooks on life.
Alexander Ward: (http://www.youtube.com/user/Wardyworks)
Dimethyltryptamine (DMT) is a psychedelic compound widespread throughout the plant kingdom, and occurs in trace amounts in mammals, including humans, where it acts as a trace amine neurotransmitter/neuromodulator. The significance of its widespread natural presence remains undetermined. Functionally, DMT is analogous to the neurotransmitter serotonin (5-HT), the hormone melatonin, and other psychedelic tryptamines, such as psilocybin.
When ingested, DMT acts as a psychedelic drug. Depending on the dose and method of administration, its subjective effects can range from short-lived milder psychedelic states to powerful immersive experiences; these are often described as a total loss of connection to conventional reality with the encounter of ineffable spiritual or alien realms.
Indigenous Amazonian Amerindian cultures consume DMT as the primary psychoactive in ayahuasca, a shamanistic brew used for divinatory and healing purposes. Pharmacologically, ayahuasca combines DMT with an MAOI, an enzyme inhibitor that allows DMT to be orally active.
DMT can produce powerful psychedelic experiences including intense visuals, euphoria and hallucinations. DMT is generally not active orally unless it is combined with a monoamine oxidase inhibitor (MAOI), without which the body quickly metabolizes orally administered DMT, preventing any hallucinogenic effect unless the DMT dose exceeds the enzymes metabolic capacity. Other means of ingestion such as smoking, injecting, or insufflating the drug can produce powerful hallucinations and entheogenic activity for a short time (usually less than half an hour), as the DMT reaches the brain before it can be metabolized by the body’s natural monoamine oxidase. Taking a MAOI prior to vaporizing or injecting DMT prolongs and potentiates the effects.
A standard dose for smoking vaporized DMT is between 15–60 mg. This is generally inhaled in a few successive breaths. The effects from smoking DMT last for a short period of time, usually 5 to 15 minutes, dependent on the dose. The onset after inhalation is very fast (less than 45 seconds) and peak effects are reached within a minute. In the 1960s, DMT was known as a “businessman’s trip” in the US because of the relatively short duration (and rapid onset) of action when vaporized.
In the UK DMT is classified as a Class A drug, while in the US it is regarded as a Schedule I drug.
DMT and ayahuasca videos on London Real:
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