As of March 17, there are over 180.000 people infected worldwide by the new coronavirus SARS-CoV-2, which can cause the coronavirus respiratory disease COVID-19. Recently the WHO named the outbreak a pandemic and now globally cases are rising sharply, outstripping the Chinese cases.
As the outbreak of the disease is reaching a high number of countries all over the world, the general public awareness and scientific interest are also on the rise. Currently, the virus virulence, how it is transmitted between humans and the possible treatments of the disease are being actively studied. As there is already a lot of information available, we have here gathered the known information on the molecular organization and structure of the virus, thus creating a dynamic and scientific accurate 3D animation of SARS-CoV-2!
We hope you like it! If so, please support our work by subscribing to our channel and visit our website focused on 3D animations of diverse biological processes: http://visual.biolution.net.
The video mentions that ACE2 cleaves the spike protein, however a publication published on March 5, 2020 showed that cleavage by the protease TPMSSR2 is required for priming the spike protein for viral entry: https://doi.org/10.1016/j.cell.2020.02.052
Thanks to Mikail Dogan, norm1124 and Levent Cavas for pointing this out!
We also apologise for referring to the hemagglutinin protein, which is of SARS-CoV. Instead SARS-CoV-2 contains a so called M Protein in the envelope. A correct Figure is here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097337/figure/Fig3/
Thanks to colicinK and Mike Sauder for pointing this out!
Please feel free to get in touch with us if you are interested in scientifically accurate high-quality animations. Email: email@example.com //
The structures used for the video can be found here:
M-protein: PDB ID 3cl4
E protein pentameric ion channel: PDB ID 5×29
Nucleocapsid: PDB ID 2GIB
Spike protein: PDB ID 5i08
Here some links with regularly updated information about the new coronavirus:
– World Health Organization – WHO: https://www.who.int/health-topics/coronavirus
– Johns Hopkins Center for Systems Science and Engineering: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
– American Centers of Disease Control and Prevention: https://www.cdc.gov/coronavirus/2019-ncov/index.html